Oct. 25, 2012 -- Over-the-counter eyedrops and nose sprays contain powerful drugs that are poisonous in surprisingly small amounts if swallowed, the FDA warns. ... Today’s Health Original Eye Drops. Typically, correct use is no more than two drops in your eyes six times a day. If you stay within these limits, your risk of bad toxicity may be relatively low. It's a different story if eye drops.